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Just got the 1050 Speed Triple SE, and I absolutely love it. Coming from my RC it was actually difficult to adjust to the more upright riding position, but it didn't take long, and I am so much more comfortable.
The S3 obviously doesn't have the LOW end grunt of the big twins, but its not really far behind. And, when the power kicks in, it really rushes in. Another legitimate consideration about the S3, the front wheel comes up VERY easily. I've considered getting clip-ons to try and make it a little more difficult to wheelie, but I'm going to stick with the bar for now, for comfort's sake.
Finally, I've still got the OEM exhaust, but I've heard aftermarket exhaust systems on the 1050 and I don't like the sound as much as the twins. Just something about the deep thump of the RC that I love.
So, big thumbs up from me regarding the Speed Triple.