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Phil, as Randy mentioned the trip down is absolutely rideable. Skyline Dr and the Blueridge are beautiful, they do suck in crappy weather though. When I ride it I'll head South after work Friday and stay in PA, hit Front Royal VA early and enjoy. If I'm camping Skyland is great, Millers Camping has no frills but it's in a good spot. More into a hotel? Blowing Rock hands down. Restaraunts, shops, a nice downtown, and usually free concerts on the common.
It's a great trip, even if you do it one way and slab or take a different route back. Make sure the camera is charged, every turn is a scenic vista (don't stop at all of them though!)