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I would say as far ass the mass of the sprockets, it's essentially not much difference at all... not that any of us could tell.
for instance, comparing a 14/42 with a 15/45 - you may may have a couple extra links w/ 15/45 and the moment will be a touch longer, but i'd say nil. Reason i recommended going down one from stock in front, and up less in the rear, because it would have saved from buying a chain. If doc's doing the chain anyway, then I suppose it's up to him... although it's been suggested that down 1 in front would be an issue.