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My chain and sprockets had 28,500 miles on them and though the chain was not requiring constant andjustment, nor were my adjusters maxed out, the chain had a wickedly pronounced tight section that prevented the proper amount of slack, so I put new parts on, on Friday. Man, what a difference that made in smoothness. If you know your chain has a loose or tight spot and the bike feels like it's running roughly at low speeds or whil accelerating, you may want to consider changing the chain and sprockets.
I went with top-shelf Regina stuff this time.